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KMID : 1149220080160020163
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 2 p.163 ~ p.169
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Study on Kidney Toxicity of BDR-29 for Treatment Vascular Diseases in Rats
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Kim Eun-Ju
Kang Dae-Gill
Lee An-Sook
Choi Deok-Ho
Cho Kuk-Hyun
Kim Sung-Yeon
Lee Ho-Sub
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Abstract
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The kidney toxicities of BDR-29 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with BDR-29, no mortality and gross pathological findings were shown for 13 weeks. There substantially was no change in body weight in all rats with treatment of BDR-29. The renal functional parameters including urinary volume, urine osmolality, electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were not exchanged in all rats treated with BDR-29. Taken together, these results suggest that BDR-29 has no toxicity on kidney in all male and female rats.
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KEYWORD
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BDR-29, Kidney toxicity, In vivo
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